Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-4-6
pubmed:abstractText
The reverse transcription polymerase chain reaction (RT-PCR) was used to assess the induction of mRNA of the proinflammatory cytokines IL-1 beta, IL-6 and TNF alpha in the spleen, pituitary, hypothalamus and hippocampus of mice after an intraperitoneal injection of lipopolysaccharide (LPS, 10 micrograms/mouse). The kinetics of cytokine gene expression induced by peripheral LPS in the pituitary and brain structures were different from that observed in the spleen. For IL-1 beta the dose-response curve was also measured and also found to be different. These results support the idea that one pathway by which peripheral immune stimuli affect brain functions includes local synthesis of proinflammatory cytokines in certain brain structures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0169-328X
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-62
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:7877446-Animals, pubmed-meshheading:7877446-Base Sequence, pubmed-meshheading:7877446-Brain, pubmed-meshheading:7877446-Dose-Response Relationship, Drug, pubmed-meshheading:7877446-Gene Expression Regulation, pubmed-meshheading:7877446-Hippocampus, pubmed-meshheading:7877446-Hypothalamus, pubmed-meshheading:7877446-Inflammation, pubmed-meshheading:7877446-Interleukin-1, pubmed-meshheading:7877446-Interleukin-6, pubmed-meshheading:7877446-Kinetics, pubmed-meshheading:7877446-Lipopolysaccharides, pubmed-meshheading:7877446-Male, pubmed-meshheading:7877446-Mice, pubmed-meshheading:7877446-Molecular Sequence Data, pubmed-meshheading:7877446-Nerve Tissue Proteins, pubmed-meshheading:7877446-Pituitary Gland, pubmed-meshheading:7877446-Spleen, pubmed-meshheading:7877446-Tumor Necrosis Factor-alpha, pubmed-meshheading:7877446-beta 2-Microglobulin
pubmed:year
1994
pubmed:articleTitle
Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice.
pubmed:affiliation
INRA-INSERM U394, Bordeaux, France.
pubmed:publicationType
Journal Article