7851786

Source:http://linkedlifedata.com/resource/pubmed/id/7851786

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002085, umls-concept:C0282688, umls-concept:C1522240, umls-concept:C1555721, umls-concept:C1706204
pubmed:issue	3
pubmed:dateCreated	1995-3-14
pubmed:abstractText	The substitution processes for various models of deleterious alleles are examined using computer simulations and mathematical analyses. Most of the work focuses on the house-of-cards model, which is a popular model of deleterious allele evolution. The rate of substitution is shown to be a concave function of the strength of selection as measured by alpha = 2N sigma, where N is the population size and sigma is the standard deviation of fitness. For alpha < 1, the house-of-cards model is essentially a neutral model; for alpha > 4, the model ceases to evolve. The stagnation for large alpha may be understood by appealing to the theory of records. The house-of-cards model evolves to a state where the vast majority of all mutations are deleterious, but precisely one-half of those mutations that fix are deleterious (the other half are advantageous). Thus, the model is not a model of exclusively deleterious evolution as is frequently claimed. It is argued that there are no biologically reasonable models of molecular evolution where the vast majority of all substitutions are deleterious. Other models examined include the exponential and gamma shift models, the Hartl-Dykhuizen-Dean (HDD) model, and the optimum model. Of all those examined, only the optimum and HDD models appear to be reasonable candidates for silent evolution. None of the models are viewed as good candidates for protein evolution, as none are both biologically reasonable and exhibit the variability in substitutions commonly observed in protein sequence data.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-1013905, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-1060137, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-14456043, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-16592725, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-1954033, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-2832690, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-3360308, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-3479776, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-5512470, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-6946514, http://linkedlifedata.com/resource/pubmed/commentcorrection/7851786-8349119
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0374636
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0016-6731
pubmed:author	pubmed-author:GillespieJ HJH
pubmed:issnType	Print
pubmed:volume	138
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	943-52
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:7851786-Alleles, pubmed-meshheading:7851786-Biological Evolution, pubmed-meshheading:7851786-Computer Simulation, pubmed-meshheading:7851786-Models, Genetic
pubmed:year	1994
pubmed:articleTitle	Substitution processes in molecular evolution. III. Deleterious alleles.
pubmed:affiliation	Section of Evolution and Ecology, University of California, Davis 95616.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S.