Linked Life Data

7843102

Source:http://linkedlifedata.com/resource/pubmed/id/7843102

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1995-3-8
pubmed:abstractText
This study was undertaken to establish whether occupational exposures to derivatives of carcinogenic metals evoke inflammatory immune responses, as determined by the presence of elevated titers of antibodies (Ab) that recognize oxidized DNA bases. Sera obtained from the blood of steel welders (Delaware) and from workers of the Centra Ni-Cd Battery Factory (Pozna?, Poland) were analyzed by the enzyme-linked immunosorbent assay. To determine specific and nonspecific binding, an oxidized thymidine [5-hydroxymethyl-2'-deoxyuridine (HMdU)] coupled to bovine serum albumin (HMdU-BSA) as well as mock-coupled BSA (M-BSA) were used as antigens for coating the wells of microtiter plates. Titers of anti-HMdU Ab were significantly elevated in the high Cd and Ni exposure groups (18.3 +/- 3.2 vs 10.8 +/- 2.1 A492/microliters; p < 0.05). The sera of the groups with low exposures to Cd and Ni also had enhanced titers of those Ab but those increases were not statistically significant. Interestingly, the Ab titers present in the sera of controls for Cd and Ni exposures appear to be constant regardless of the protein content. In contrast, both lightly and heavily exposed subjects exhibited Ab titers that increased with increasing protein content. When 12 randomly selected workers (4 from each of the control, lightly, and heavily exposed groups) were outfitted with personal monitors, anti-HMdU Ab titers of those workers showed a significant difference between the groups with light (< 100 micrograms/m3) and heavy (> 200 micrograms/m3) exposures to Cd (9.8 +/- 3.7 vs 22.1 +/- 3.7 A492/microliters; p < 0.01) and Ni (11.7 +/- 1.4 vs 31.0 +/- 1.8; p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-1365325, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-14192660, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-1641400, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-1807442, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-1807443, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-1807444, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-2253206, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-2663022, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-2855733, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-3567930, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-6376103, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-6376104, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-8342966, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-8349138, http://linkedlifedata.com/resource/pubmed/commentcorrection/7843102-8511780
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0091-6765
pubmed:author
pubmed:issnType
Print
pubmed:volume
102 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Occupational exposures to Cd, Ni, and Cr modulate titers of antioxidized DNA base autoantibodies.
pubmed:affiliation
Department of Environmental Medicine, New York University Medical Center, New York.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial