Linked Life Data

7839366

Source:http://linkedlifedata.com/resource/pubmed/id/7839366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-2-24
pubmed:abstractText
This study was performed to determine the effect of cisplatin (cis-diamminedichloroplatinum II) on renal function in rabbits. Injection of a single i.p. dose of 4 mg/kg cisplatin caused an increase in fractional excretion of Na+ and K+ and a decrease in urine osmolality (Uosm), free-water reabsorption, (TcH2O), and urine to plasma creatinine ratio (U/Pcr). Urine flow was decreased following cisplatin treatment, which was accompanied by marked reduction in GFR. Cisplatin induced glucosuria, phosphaturia, and aminoaciduria. These results suggest that cisplatin results in impaired proximal tubular reabsorptive function and the renal concentrating defect. Cisplatin treatment impaired the accumulation of PAH and TEA and ouabain-sensitive oxygen consumption in renal cortical slices. Na(+)-K(+)-ATPase activity in renal cortical microsomes and basolateral membrane vesicles was significantly depressed in cisplatin-treated animals. Cisplatin treatment did not affect the Na(+)-dependent uptake of glucose and L-glutamate by brush-border membrane vesicles (BBMV), but caused a significant decrease in Na(+)-dependent succinate and H(+)-dependent TEA uptake. Morphological observations showed that cisplatin caused a focal loss of the microvillus brush border. These results suggest that (1) cisplatin induces oliguric acute renal failure in rabbits and (2) glucosuria induced by cisplatin was not due to a direct impairment of glucose transporter in brush-border membranes but due to an inhibition of Na(+)-pump activity and a decrease in area for active glucose reabsorption in the proximal tubule.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-26
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:7839366-Amino Acids, pubmed-meshheading:7839366-Animals, pubmed-meshheading:7839366-Blood Urea Nitrogen, pubmed-meshheading:7839366-Cell Membrane, pubmed-meshheading:7839366-Cisplatin, pubmed-meshheading:7839366-Creatinine, pubmed-meshheading:7839366-Glomerular Filtration Rate, pubmed-meshheading:7839366-Glutamic Acid, pubmed-meshheading:7839366-Glycosuria, pubmed-meshheading:7839366-Injections, Intraperitoneal, pubmed-meshheading:7839366-Kidney Cortex, pubmed-meshheading:7839366-Kidney Tubules, Proximal, pubmed-meshheading:7839366-Microscopy, Electron, pubmed-meshheading:7839366-Microsomes, pubmed-meshheading:7839366-Microvilli, pubmed-meshheading:7839366-Monosaccharide Transport Proteins, pubmed-meshheading:7839366-Osmolar Concentration, pubmed-meshheading:7839366-Ouabain, pubmed-meshheading:7839366-Oxygen Consumption, pubmed-meshheading:7839366-Phosphates, pubmed-meshheading:7839366-Potassium, pubmed-meshheading:7839366-Rabbits, pubmed-meshheading:7839366-Sodium, pubmed-meshheading:7839366-Sodium-Potassium-Exchanging ATPase
pubmed:year
1995
pubmed:articleTitle
Effect of cisplatin on renal function in rabbits: mechanism of reduced glucose reabsorption.
pubmed:affiliation
Department of Physiology, College of Medicine, Pusan National University, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't