Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1995-2-27
pubmed:abstractText
1. Mucosally added synthetic guanylin and Escherichia coli heat-stable enterotoxin (STa) increased short-circuit current (ISC) across isolated muscle-stripped human intestine in vitro. 2. Serosal bumetanide inhibited ISC responses indicating that guanylin and STa stimulate electrogenic chloride secretion. 3. ISC responses were markedly greater in the colon than in the jejunum. 4. Pretreatment with indomethacin did not significantly alter the effects of guanylin and STa. 5. Both peptides induced concentration-dependent increases in the cyclic GMP content of human intestinal mucosa in vitro; cyclic AMP levels remained unchanged. 6. In contrast to ISC responses, increases in cyclic GMP content induced by guanylin and STa were markedly greater in the jejunum than in the colon. 7. Sodium nitroprusside (SNP) but not human alpha-atrial natriuratic peptide (CDD/ANP(99-126)) increased chloride secretion in human intestine; both agents induced small increases in intestinal cyclic GMP content. 8. Guanylin, STa and the nitric oxide (NO) donor SNP increased electrogenic chloride secretion across human intestinal mucosa in vitro by stimulation of cyclic GMP. The discrepancy between the effects on chloride secretion and intracellular cyclic GMP content suggest different cellular action sites of guanylin and STa in human small and large intestine.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-1346555, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-1378267, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-1409606, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-1566853, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-1681902, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-1724966, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-2406887, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-26915, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-2750902, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-2885801, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-31794, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-365740, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-7504643, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-7684181, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-8006834, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-8095028, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-8103637, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-8104900, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-8381596, http://linkedlifedata.com/resource/pubmed/commentcorrection/7837099-8390480
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins, http://linkedlifedata.com/resource/pubmed/chemical/Chloride Channels, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP, http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins, http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Hormones, http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin, http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/guanylin, http://linkedlifedata.com/resource/pubmed/chemical/heat stable toxin (E coli)
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
479 ( Pt 3)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
433-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Segmental differences in the effects of guanylin and Escherichia coli heat-stable enterotoxin on Cl- secretion in human gut.
pubmed:affiliation
Lower Saxony Institute for Peptide Research, Hannover, Germany.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't