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rdf:type |
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lifeskim:mentions |
umls-concept:C0019630,
umls-concept:C0026809,
umls-concept:C0027651,
umls-concept:C0035015,
umls-concept:C0042210,
umls-concept:C0104998,
umls-concept:C0431085,
umls-concept:C1548437,
umls-concept:C1705431,
umls-concept:C1882923,
umls-concept:C1948023
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pubmed:issue |
2
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pubmed:dateCreated |
1995-2-24
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pubmed:abstractText |
Mice carrying large established major histocompatibility complex (MHC) class 1+ sarcoma tumors can be successfully treated by immunization with genetically engineered sarcoma cells transfected with syngeneic MHC class II plus B7-1 genes. This approach is significantly more effective than previously described strategies using cytokine- or B7-transduced tumor cells which are only effective against smaller tumor loads, and which cannot mediate regression of longer-term established tumors. The most efficient tumor rejection occurs if both the class II and B7-1 molecules are coexpressed on the same tumor cell. Immunity induced by immunization with class II+B7-1(+)-transfected sarcoma cells involves CD4+ and CD8+ T cells, suggesting that the increased effectiveness of the transfectants is due to their ability to activate both of these T cell populations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-1279442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-1281187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-1335364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-1349172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-1918972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-1948050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-1967486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-2332639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-2388037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-2653373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-2784508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-567555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-6159417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-6195255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-6935293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-7507508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-7515929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-7678351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-7684435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-7685909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-7694593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-7903204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-8097319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-8133027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-8168141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-8245467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-8326126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-8383716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-8455201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7836917-8459207
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
181
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pubmed:geneSymbol |
B7-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
619-29
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7836917-Animals,
pubmed-meshheading:7836917-Cells, Cultured,
pubmed-meshheading:7836917-Female,
pubmed-meshheading:7836917-Histocompatibility Antigens Class II,
pubmed-meshheading:7836917-Immunotherapy,
pubmed-meshheading:7836917-Male,
pubmed-meshheading:7836917-Mice,
pubmed-meshheading:7836917-Mice, Nude,
pubmed-meshheading:7836917-Sarcoma, Experimental,
pubmed-meshheading:7836917-Transfection,
pubmed-meshheading:7836917-Vaccines, Synthetic
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pubmed:year |
1995
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pubmed:articleTitle |
Major histocompatibility complex class II+B7-1+ tumor cells are potent vaccines for stimulating tumor rejection in tumor-bearing mice.
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pubmed:affiliation |
Department of Biological Sciences, University of Maryland, Baltimore 21228.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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