Linked Life Data

7830256

Source:http://linkedlifedata.com/resource/pubmed/id/7830256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1995-2-17
pubmed:abstractText
A computer optimization technique based on response surface methodology was applied for the optimization of a hydrogel formulation containing indomethacin as a model drug. As the penetration enhancer, a combination of three cyclic monoterpenes, limonene, menthol, and cineole, was employed. Pharmacokinetic parameters, from an in vivo percutaneous absorption study on rats of model formulations prepared according to the composite experimental design for five factors, were determined as prime response variables. The skin damage evoked by each formulation was microscopically judged and graded as the response variable concerning skin safety. The response variables were predicted by multiple regression equations comprising combinations of the five formulation factors. The regression equations for the response variables assembled as a simultaneous optimization problem based on the generalized distance function. The simultaneous optimum was predicted as a function of individual optima within a 95% confidence region. The predicted response values for the optimum formulation have been successfully validated in a repeated in vivo percutaneous absorption study.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1367-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers.
pubmed:affiliation
Department of Pharmaceutics, Hoshi University, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't