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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
14
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pubmed:dateCreated |
1995-2-22
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pubmed:abstractText |
Long-term depression of field excitatory postsynaptic potentials (EPSP) in the CA1 region of hippocampal slices was evoked by delivering a 15 min train of pulses at 1 Hz to the Schaffer-commissural-CA1 pathway, and prevented by adding an N-methyl-D-aspartate (NMDA) receptor antagonist (AP-5, 50 microM) to the perfusing medium. Superfusion of the slices with Cs (2 mM) during the 1 Hz stimulation period could both inhibit the maintenance phase of the depression itself and elicit spontaneous rhythmic activity. Cs had no effect on the postsynaptic response to the GABA-B agonist, baclofen. As a major effect of Cs is a block of the hyperpolarization-activated current (Ih), these results suggest the possible involvement of Ih in the maintenance of long-term depression.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
pubmed:issn |
0959-4965
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
8
|
pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1813-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7827339-2-Amino-5-phosphonovalerate,
pubmed-meshheading:7827339-Animals,
pubmed-meshheading:7827339-Cesium,
pubmed-meshheading:7827339-Depression, Chemical,
pubmed-meshheading:7827339-Electric Stimulation,
pubmed-meshheading:7827339-Hippocampus,
pubmed-meshheading:7827339-Male,
pubmed-meshheading:7827339-Neuronal Plasticity,
pubmed-meshheading:7827339-Neurons,
pubmed-meshheading:7827339-Rats,
pubmed-meshheading:7827339-Rats, Wistar,
pubmed-meshheading:7827339-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
1994
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pubmed:articleTitle |
Cesium prevents maintenance of long-term depression in rat hippocampal CA1 neurons.
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pubmed:affiliation |
Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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