Linked Life Data

7819531

Source:http://linkedlifedata.com/resource/pubmed/id/7819531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1995-2-10
pubmed:abstractText
The present study investigated the regulation of opioid receptors following chronic repeated cocaine administration. Male Fischer rats were injected with saline or cocaine, 45 mg kg-1 day-1, three times daily at 1 h intervals for 14 days. Using quantitative in vitro autoradiography, the density of kappa receptors was significantly higher in the rostral cingulate cortex, rostral caudate putamen, caudal olfactory tubercle, and ventral tegmental area following cocaine administration. No changes in delta receptor number were detected in any brain region examined. Significant mu receptor upregulation was found in the rostral cingulate cortex, nucleus accumbens, rostral caudate putamen, and basolateral amygdala nucleus of the cocaine-treated animals. These results suggest that enhanced dopaminergic activity can regulate mu and kappa opioid receptors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1613-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors.
pubmed:affiliation
Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10021.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't