|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1995-2-8
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|
pubmed:abstractText |
Kaplan-Meier risks estimates are calculated and compared for two consecutive series (N1 = 840, N2 = 819) of first-degree relatives of Alzheimer disease (AD) patients diagnosed as either "probable" or "autopsy-confirmed" AD. The consistency of results increases confidence in estimates and suggests consistent case ascertainment over 8 years. Lifetime risk estimates to age 88 for the combined sample (23.4% +/- 3.0%) do not approach the 50% risk compatible with an autosomal dominant model of transmission. These results support our previous finding and suggest that an autosomal dominant gene(s) is not responsible for all cases of AD.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0741-0395
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
365-74
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|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:7813898-Aged,
pubmed-meshheading:7813898-Aged, 80 and over,
pubmed-meshheading:7813898-Alzheimer Disease,
pubmed-meshheading:7813898-Bias (Epidemiology),
pubmed-meshheading:7813898-British Columbia,
pubmed-meshheading:7813898-Cross-Sectional Studies,
pubmed-meshheading:7813898-Female,
pubmed-meshheading:7813898-Genes, Dominant,
pubmed-meshheading:7813898-Genetics, Population,
pubmed-meshheading:7813898-Humans,
pubmed-meshheading:7813898-Incidence,
pubmed-meshheading:7813898-Longitudinal Studies,
pubmed-meshheading:7813898-Male,
pubmed-meshheading:7813898-Models, Genetic,
pubmed-meshheading:7813898-Molecular Epidemiology,
pubmed-meshheading:7813898-Morbidity,
pubmed-meshheading:7813898-Pedigree,
pubmed-meshheading:7813898-Population Surveillance,
pubmed-meshheading:7813898-Proportional Hazards Models,
pubmed-meshheading:7813898-Risk Factors
|
|
pubmed:year |
1994
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|
pubmed:articleTitle |
Familial risks for Alzheimer disease from a population-based series.
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|
pubmed:affiliation |
Department of Medical Genetics, University Hospital-UBC Site, University of British Columbia, Vancouver, Canada.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Review,
Research Support, Non-U.S. Gov't
|
