7813561

Source:http://linkedlifedata.com/resource/pubmed/id/7813561

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011570, umls-concept:C0058697, umls-concept:C0233488, umls-concept:C0243192, umls-concept:C0599779, umls-concept:C1280500
pubmed:issue	1-2
pubmed:dateCreated	1995-2-8
pubmed:abstractText	We compared the effect of two selective dopamine D1 receptor agonists, SKF 38393 ((+/-)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol.HCl) and A68930 ((1R,3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman.HCl), and that of imipramine in the behavioural despair model of depression. The dopamine D1 receptor agonists and imipramine showed an anti-immobility effect. Moreover we found that the 'antidepressant' effect of imipramine in the behavioural despair test was antagonized by SCH 23390, a selective dopamine D1 receptor blocker. The results further support the hypothesis that dopamine D1 receptor stimulation plays an important role in the mechanism of action of antidepressants and suggest that dopamine D1 receptor agonists might be considered as potential antidepressant drugs.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/1254354
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-p..., http://linkedlifedata.com/resource/pubmed/chemical/A 68930, http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines, http://linkedlifedata.com/resource/pubmed/chemical/Chromans, http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Imipramine, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0014-2999
pubmed:author	pubmed-author:ColloGG, pubmed-author:D'AquilaP SPS, pubmed-author:GessaG LGL, pubmed-author:KüngJJ, pubmed-author:SerraGG
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	262
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	107-11
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:7813561-2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, pubmed-meshheading:7813561-Analysis of Variance, pubmed-meshheading:7813561-Animals, pubmed-meshheading:7813561-Antidepressive Agents, pubmed-meshheading:7813561-Behavior, Animal, pubmed-meshheading:7813561-Benzazepines, pubmed-meshheading:7813561-Chromans, pubmed-meshheading:7813561-Depression, pubmed-meshheading:7813561-Disease Models, Animal, pubmed-meshheading:7813561-Dopamine Agonists, pubmed-meshheading:7813561-Dose-Response Relationship, Drug, pubmed-meshheading:7813561-Imipramine, pubmed-meshheading:7813561-Injections, Intraperitoneal, pubmed-meshheading:7813561-Injections, Subcutaneous, pubmed-meshheading:7813561-Male, pubmed-meshheading:7813561-Motor Activity, pubmed-meshheading:7813561-Rats, pubmed-meshheading:7813561-Rats, Sprague-Dawley, pubmed-meshheading:7813561-Receptors, Dopamine D1, pubmed-meshheading:7813561-Stereoisomerism
pubmed:year	1994
pubmed:articleTitle	Antidepressant-like effect of selective dopamine D1 receptor agonists in the behavioural despair animal model of depression.
pubmed:affiliation	B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't