| pubmed-article:7812625 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7812625 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:7812625 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:7812625 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:7812625 | lifeskim:mentions | umls-concept:C0040578 | lld:lifeskim |
| pubmed-article:7812625 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:7812625 | lifeskim:mentions | umls-concept:C1323606 | lld:lifeskim |
| pubmed-article:7812625 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:7812625 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:7812625 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7812625 | pubmed:dateCreated | 1995-2-8 | lld:pubmed |
| pubmed-article:7812625 | pubmed:abstractText | Phosphodiesterase (PDE) activities that were capable of hydrolysing cyclic AMP (Km = 6.8 +/- 2 microM) and cyclic GMP (Km = 6.7 +/- 1.6 microM) were isolated from tracheal smooth muscle. These enzyme(s) activities were insensitive to stimulation by calcium/calmodulin and to inhibition by cyclic GMP, rolipram (type IV inhibitor) and siguazodan (type III inhibitor). Zaprinast was a relatively poor inhibitor of both cyclic AMP and cyclic GMP hydrolysis (IC50 = 46 +/- 9 microM and 45 +/- 14 microM respectively). These results suggest that tracheal smooth muscle may contain an apparently novel PDE. However, KCl (30 mM) which facilitates calcium entry in cells, depressed bradykinin-stimulated intracellular cyclic AMP formation, suggesting that the type I PDE may be functionally present. We suggest that considerable caution be exercised in identifying apparently novel PDE isoforms. | lld:pubmed |
| pubmed-article:7812625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7812625 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7812625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812625 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7812625 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7812625 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7812625 | pubmed:author | pubmed-author:SterlinA IAI | lld:pubmed |
| pubmed-article:7812625 | pubmed:author | pubmed-author:BurnsFF | lld:pubmed |
| pubmed-article:7812625 | pubmed:author | pubmed-author:PyneN JNJ | lld:pubmed |
| pubmed-article:7812625 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7812625 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:7812625 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7812625 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7812625 | pubmed:pagination | 3-4 | lld:pubmed |
| pubmed-article:7812625 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:meshHeading | pubmed-meshheading:7812625-... | lld:pubmed |
| pubmed-article:7812625 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7812625 | pubmed:articleTitle | The identification of apparently novel cyclic AMP and cyclic GMP phosphodiesterase activities in guinea-pig tracheal smooth muscle. | lld:pubmed |
| pubmed-article:7812625 | pubmed:affiliation | Department of Physiology and Pharmacology, Strathclyde University, Glasgow. | lld:pubmed |
| pubmed-article:7812625 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7812625 | pubmed:publicationType | In Vitro | lld:pubmed |
