| pubmed-article:7798940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0087140 | lld:lifeskim |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:7798940 | lifeskim:mentions | umls-concept:C0205248 | lld:lifeskim |
| pubmed-article:7798940 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7798940 | pubmed:dateCreated | 1995-1-24 | lld:pubmed |
| pubmed-article:7798940 | pubmed:abstractText | Neurons from the granular layer of the cerebellum express functional beta 2-adrenoreceptors (beta 2-ARs). We show that stimulation of beta 2-ARs with isoprenaline increases cyclic AMP (cAMP) production and stimulates transcription of genes containing the cAMP-responsive element (CRE; TGACGTCA). This effect is mediated by cAMP-dependent protein kinase and the trans-acting factor CRE binding protein. Transcriptional regulation by the beta 2-AR was investigated by using the c-fos protooncogene as a model system. We show that beta 2-ARs stimulate c-fos mRNA accumulation, increase AP1 binding activity, and stimulate transcription through the phorbol ester-responsive element (TGACTCA). The transcriptional regulation of c-fos itself was studied with reporter constructs driven by c-fos promoter sequences. Deletion studies revealed that beta 2-ARs stimulate c-fos transcription through at least three distinct regulatory sequences: (a) the CRE located at -60 bp 5' to the initiation site, (b) the fos AP1-like element (-291 to -297), and (c) the serum-responsive element (-297 to -317). The regulation of these elements by the two putative second messengers of the beta 2-AR, cAMP and Ca2+, was analyzed. We report that all three of these regulatory sequences are coregulated by both second messengers. These results indicate that beta 2-ARs stimulate c-fos transcription by multiple cAMP- and Ca(2+)-dependent regulatory elements in neurons. | lld:pubmed |
| pubmed-article:7798940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7798940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7798940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7798940 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7798940 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:7798940 | pubmed:author | pubmed-author:BarthelFF | lld:pubmed |
| pubmed-article:7798940 | pubmed:author | pubmed-author:LoefflerJ PJP | lld:pubmed |
| pubmed-article:7798940 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7798940 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:7798940 | pubmed:geneSymbol | c-fos | lld:pubmed |
| pubmed-article:7798940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7798940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7798940 | pubmed:pagination | 41-51 | lld:pubmed |
| pubmed-article:7798940 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
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| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
| pubmed-article:7798940 | pubmed:meshHeading | pubmed-meshheading:7798940-... | lld:pubmed |
| pubmed-article:7798940 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7798940 | pubmed:articleTitle | Beta 2-adrenoreceptors stimulate c-fos transcription through multiple cyclic AMP- and Ca(2+)-responsive elements in cerebellar granular neurons. | lld:pubmed |
| pubmed-article:7798940 | pubmed:affiliation | Institut de Physiologie et de Chimie Biologique, URA 1446 du CNRS, Strasbourg, France. | lld:pubmed |
| pubmed-article:7798940 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7798940 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
