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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
51
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pubmed:dateCreated |
1995-1-24
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pubmed:abstractText |
Glucose stimulation of beta-cell insulin secretion is initiated by membrane depolarization coupled with an elevation in intracellular Ca2+ concentration ([Ca2+]i). Both depolarization-dependent Ca2+ entry and intracellular Ca2+ store release contribute to the sugar-induced rise in [Ca2+]i. Here we show that maneuvers depleting intracellular Ca2+ stores induce membrane depolarization and a sustained nitrendipine-sensitive Ca2+ influx, whereas interventions promoting Ca2+ store refilling produce a hyperpolarization and inhibit Ca2+ influx. Both intracellular Ca2+ store depletion and maitotoxin activated a depolarizing nonselective cation current carried principally by Na+ in the physiological range of membrane potentials. The activation of such a current may form the paradigm by which excitable cells refill depleted intracellular Ca2+ stores by depolarization-driven opening of voltage-activated Ca2+ channels.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Marine Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxocins,
http://linkedlifedata.com/resource/pubmed/chemical/maitotoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9258
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
23
|
pubmed:volume |
269
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
32055-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7798198-Animals,
pubmed-meshheading:7798198-Calcium,
pubmed-meshheading:7798198-Calcium Channels,
pubmed-meshheading:7798198-Islets of Langerhans,
pubmed-meshheading:7798198-Marine Toxins,
pubmed-meshheading:7798198-Membrane Potentials,
pubmed-meshheading:7798198-Mice,
pubmed-meshheading:7798198-Mice, Inbred C57BL,
pubmed-meshheading:7798198-Oxocins
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pubmed:year |
1994
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pubmed:articleTitle |
Depletion of intracellular Ca2+ stores activates a maitotoxin-sensitive nonselective cationic current in beta-cells.
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pubmed:affiliation |
Department of Cell Physiology, Glaxo Research Institute, Research Triangle Park, North Carolina 27709.
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pubmed:publicationType |
Journal Article,
In Vitro
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