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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
1995-7-26
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pubmed:abstractText |
We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12-->q13.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-0171
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:geneSymbol |
FLT3,
flk2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
255-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7789184-Animals,
pubmed-meshheading:7789184-Base Sequence,
pubmed-meshheading:7789184-Bone Marrow,
pubmed-meshheading:7789184-Chromosome Mapping,
pubmed-meshheading:7789184-Chromosomes, Human, Pair 13,
pubmed-meshheading:7789184-DNA Primers,
pubmed-meshheading:7789184-Hematopoietic Stem Cells,
pubmed-meshheading:7789184-Humans,
pubmed-meshheading:7789184-Hybrid Cells,
pubmed-meshheading:7789184-In Situ Hybridization, Fluorescence,
pubmed-meshheading:7789184-Mice,
pubmed-meshheading:7789184-Molecular Sequence Data,
pubmed-meshheading:7789184-Polymerase Chain Reaction,
pubmed-meshheading:7789184-Proto-Oncogene Proteins,
pubmed-meshheading:7789184-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:7789184-Receptors, Cell Surface,
pubmed-meshheading:7789184-fms-Like Tyrosine Kinase 3
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pubmed:year |
1995
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pubmed:articleTitle |
Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12-->q13.
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pubmed:affiliation |
Oncology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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