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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1976-8-23
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pubmed:abstractText |
This report describes the first fine structural locations of S-100 protein in the hamster cerebellum. Innovations in tissue fixation as well as tracer preparation enable localization of S-100 protein to several critical cellular and subcellular sites. Certain neuronal elements, Purkinje cells, contain S-100 protein in both cytoplasm and nucleus. Specific membrane structures including plasma membranes and the nuclear membranes of Purkinje cells are strikingly positive. Localization of S-100 protein to the pericapillary astrocytic endfeet as well as regions of the synapse are of particular biological interest. The clear nuclear localization of the molecule suggests a role in the genetic expression of the developing mammalian brain.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-510X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-76
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:778346-Animals,
pubmed-meshheading:778346-Cerebellum,
pubmed-meshheading:778346-Cricetinae,
pubmed-meshheading:778346-Endoplasmic Reticulum,
pubmed-meshheading:778346-Fluorescent Antibody Technique,
pubmed-meshheading:778346-Microscopy, Electron,
pubmed-meshheading:778346-Mitochondria,
pubmed-meshheading:778346-Nerve Tissue Proteins,
pubmed-meshheading:778346-Neuroglia,
pubmed-meshheading:778346-Purkinje Cells,
pubmed-meshheading:778346-S100 Proteins
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pubmed:year |
1976
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pubmed:articleTitle |
The fine structural localization of S-100 protein in rodent cerebellum.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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