Linked Life Data

7781689

Source:http://linkedlifedata.com/resource/pubmed/id/7781689

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1995-7-18
pubmed:abstractText
Neuropeptide Y is a powerful vasoconstrictor in vivo; however, in vitro it shows weak constrictor effects. This discrepancy may have led to conflicting reports concerning the contractile effects of neuropeptide Y on isolated blood vessels. Using isolated rat tail and femoral artery segments neuropeptide Y (0.1-100 nM) did not induce any contractile response. However, if the catecholamine neuronal uptake blocker cocaine was added to the tissue bath, neuropeptide Y induced a contraction which could be fully blocked by prazosin (1000 nM). Furthermore, an age-dependent increase in the contraction to neuropeptide Y plus cocaine was observed. In conclusion, in the rat tail artery an apparent direct vasoconstrictor effect of neuropeptide Y occurs only in the presence of cocaine. Since this contraction can be fully blocked by prazosin, spontaneously released norepinephrine is an important component of the contraction. The discrepancy between in vivo and in vitro effects of neuropeptide Y may be explained in part by the presence of circulating vasoconstrictors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
276
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Cocaine promotes an apparent direct vasoconstrictor effect of neuropeptide Y in the rat tail artery.
pubmed:affiliation
Department of Pharmacology, College of Medicine, University of California, Irvine 92717, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.