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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1995-6-29
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pubmed:databankReference |
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pubmed:abstractText |
The p53 protein activates transcription of a target gene by binding to a specific DNA response element and interacting with the transcriptional apparatus of RNA polymerase II. The amino-terminal domain of p53 interacts with a component of the TFIID basal transcription complex. The human TATA-binding-protein-associated factor TAFII31, a component of TFIID, has been identified as a critical protein required for p53-mediated transcriptional activation. TAFII31 and p53 proteins bind to each other via amino acid residues in the amino-terminal domain of p53 that are essential for transcription. Antibodies directed against TAFII31 protein inhibit p53-activated but not basal transcription in vitro. These results demonstrate that TAFII31 is a coactivator for the p53 protein.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1321401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1398073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1423616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1495560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1535557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1719467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1729613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1733973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1876184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1946417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-1956398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-2144363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-2144364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-2175676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-218111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-222475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-2247058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-2525423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-2642977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-3925456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-6277513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-7809597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-7917332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-7923369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-7923382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-7926727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8023157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8156597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8201258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8221891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8242752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8276238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8276239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8276240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8319905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8401585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761466-8434126
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5154-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7761466-Amino Acid Sequence,
pubmed-meshheading:7761466-Animals,
pubmed-meshheading:7761466-Base Sequence,
pubmed-meshheading:7761466-Cell Line,
pubmed-meshheading:7761466-Drosophila,
pubmed-meshheading:7761466-Gene Expression,
pubmed-meshheading:7761466-HeLa Cells,
pubmed-meshheading:7761466-Humans,
pubmed-meshheading:7761466-Molecular Sequence Data,
pubmed-meshheading:7761466-Recombinant Proteins,
pubmed-meshheading:7761466-Sequence Homology, Amino Acid,
pubmed-meshheading:7761466-Spodoptera,
pubmed-meshheading:7761466-TATA-Binding Protein Associated Factors,
pubmed-meshheading:7761466-Trans-Activators,
pubmed-meshheading:7761466-Transcription, Genetic,
pubmed-meshheading:7761466-Transcription Factor TFIID,
pubmed-meshheading:7761466-Transcription Factors,
pubmed-meshheading:7761466-Transcriptional Activation,
pubmed-meshheading:7761466-Transfection,
pubmed-meshheading:7761466-Tumor Suppressor Protein p53
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pubmed:year |
1995
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pubmed:articleTitle |
Human TAFII31 protein is a transcriptional coactivator of the p53 protein.
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pubmed:affiliation |
Department of Molecular Biology, Princeton University, NJ 08544-1014, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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