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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1995-6-29
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pubmed:abstractText |
Mouse mammary tumor virus (MMTV) encodes a superantigen that is important for viral infectivity in vivo. To determine whether superantigen function was required for infection by milk-borne MMTV, we created HYB PRO/Cla transgenic mice. These mice produced a full-length, packaged viral RNA with a frameshift mutation that caused premature termination of the superantigen protein. Young HYB PRO/Cla mice showed no deletion of their cognate V beta 14+ T cells, although they shed virus in their milk. The nontransgenic offspring of the HYB PRO/Cla mice were infected with this virus, since transgene-specific viral transcripts were detected in their mammary glands. Surprisingly, these offspring demonstrated the progressive deletion of V beta 14+ T cells characteristic of exogenous MMTV (C3H) infection. Sequence analysis demonstrated that these newly acquired viruses had reconstituted superantigen open reading frames resulting from recombination between the HYB PRO/Cla and endogenous Mtv-1 proviral RNAs. Thus, there is selection during the infection process for MMTVs with functional superantigen genes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-1316806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-1316932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-1372369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-1690424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-1700865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-1706480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-1848685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-198552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-2168108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-2501444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-2839721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-2849114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-2915387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-3033291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-6287466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-6310597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-7913038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-8035502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-8163931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-8223852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-8294859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-8382394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-8387455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-8394220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761408-89801
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4828-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7761408-Amino Acid Sequence,
pubmed-meshheading:7761408-Animals,
pubmed-meshheading:7761408-Antigens, Viral,
pubmed-meshheading:7761408-Base Sequence,
pubmed-meshheading:7761408-DNA Primers,
pubmed-meshheading:7761408-Female,
pubmed-meshheading:7761408-Flow Cytometry,
pubmed-meshheading:7761408-Gene Library,
pubmed-meshheading:7761408-Male,
pubmed-meshheading:7761408-Mammary Tumor Virus, Mouse,
pubmed-meshheading:7761408-Mice,
pubmed-meshheading:7761408-Mice, Inbred C3H,
pubmed-meshheading:7761408-Mice, Inbred Strains,
pubmed-meshheading:7761408-Mice, Transgenic,
pubmed-meshheading:7761408-Molecular Sequence Data,
pubmed-meshheading:7761408-Pedigree,
pubmed-meshheading:7761408-Polymerase Chain Reaction,
pubmed-meshheading:7761408-Recombination, Genetic,
pubmed-meshheading:7761408-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7761408-Superantigens,
pubmed-meshheading:7761408-T-Lymphocytes,
pubmed-meshheading:7761408-Transcription, Genetic
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pubmed:year |
1995
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pubmed:articleTitle |
Mouse mammary tumor viruses with functional superantigen genes are selected during in vivo infection.
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pubmed:affiliation |
Department of Microbiology/Cancer Center, University of Pennsylvania, Philadelphia 19104-6142, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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