Linked Life Data

7752110

Source:http://linkedlifedata.com/resource/pubmed/id/7752110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1995-6-22
pubmed:abstractText
Inflammation is now generally accepted as a component in the course of most patients with symptomatic osteoarthritis (OA), although the stage at which it occurs and how it affects the course has not been resolved. When joint effusions are present in OA they almost always contain more leukocytes than normal synovial fluid, although often still falling into what was considered a noninflammatory range. Multiple factors can contribute to this low grade inflammation, with crystals being only one of many such factors needing consideration. Crystals of calcium pyrophosphate dihydrate (CPPD) and apatite are more frequent in more severe radiographic OA, but whether these are a result, a contributing factor, or both is not known. Experimental studies and the few clinical observations do not show that either CPPD or apatite consistently cause either inflammation or more rapid destruction in OA. These attempts at correlations are plagued with technical questions about what crystal numbers may be meaningful, and about techniques for crystal identification. Continued efforts are indicated to identify a treatable component of OA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0380-0903
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Synovial inflammation, crystals, and osteoarthritis.
pubmed:affiliation
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.