Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-6-20
|
| pubmed:abstractText |
Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied. Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month. The remaining 36 patients, aged 69.6 +/- 1.4 years (19 +/- 3 YSM), were given only 500 mg of elemental calcium for 10 days each month. All patients underwent clinical and analytical evaluation every 3 months. Radiological evaluation, assessment of vertebral deformities, and metacarpal radiogrammetry were done every 6 months. Densitometric measurements of total and regional bone mass were made every 12 months. At 24 months, the calcitonin group showed a 60% reduction in the number of new fractures and the group receiving only calcium had a 45% increase (P < 0.001). The incidence of vertebral fractures was 0.07 per patient-year in the group treated with calcitonin and 0.45 per patient-year in the group treated with calcium (P < 0.001). At 2 years, the calcitonin group showed a 12% increase in cortical bone mass on metacarpal radiogrammetry, a 16% increase in the axial skeleton on trunk densitometry, a 3.5% increase in total body bone mineral content, a 30.7% increase in pelvic bone mineral content, and a 6.2% increase in arm bone mineral content (all P < 0.001). In the group treated with calcium alone there was a loss of bone mass in every region. These findings suggest that salmon calcitonin is effective in the treatment of osteoporosis and show that it acts on cortical and trabecular bone.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0171-967X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
181-5
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7750020-Absorptiometry, Photon,
pubmed-meshheading:7750020-Aged,
pubmed-meshheading:7750020-Arm,
pubmed-meshheading:7750020-Biological Markers,
pubmed-meshheading:7750020-Bone Density,
pubmed-meshheading:7750020-Calcitonin,
pubmed-meshheading:7750020-Calcium,
pubmed-meshheading:7750020-Chi-Square Distribution,
pubmed-meshheading:7750020-Female,
pubmed-meshheading:7750020-Follow-Up Studies,
pubmed-meshheading:7750020-Humans,
pubmed-meshheading:7750020-Injections, Intramuscular,
pubmed-meshheading:7750020-Metacarpus,
pubmed-meshheading:7750020-Osteoporosis, Postmenopausal,
pubmed-meshheading:7750020-Pelvic Bones,
pubmed-meshheading:7750020-Prospective Studies,
pubmed-meshheading:7750020-Risk Factors,
pubmed-meshheading:7750020-Spinal Fractures,
pubmed-meshheading:7750020-Spine
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Total and regional bone mineral content and fracture rate in postmenopausal osteoporosis treated with salmon calcitonin: a prospective study.
|
| pubmed:affiliation |
Department of Medicine, University Hospital of Alcalá de Henares, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|