Linked Life Data

7746832

Source:http://linkedlifedata.com/resource/pubmed/id/7746832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-6-13
pubmed:abstractText
N-Methyl-D-aspartate (NMDA) receptor activity was determined by measurement of L-glutamate-stimulated increases in free intracellular calcium concentrations (Cai) in membrane vesicles isolated from mouse hippocampi. Incubation with anesthetic concentrations of the volatile general anesthetics, halothane, enflurane, and diethyl ether, inhibited NMDA responses. The n-alcohols, ethanol, propanol, butanol and pentanol inhibited NMDA receptor responses, but methanol was ineffective. The ability of volatile anesthetics and n-alcohols to inhibit NMDA responses appears to be unrelated to the ability of some of these agents to increase resting Cai since no correlation occurred between the two effects. The results of this study show that hippocampal NMDA receptors are sensitive to inhibition by volatile general anesthetics and n-alcohols. This effect may, in part, underlie their anesthetic effects in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0031-7012
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
154-61
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Effect of volatile general anesthetics and n-alcohols on glutamate-stimulated increases in calcium ion flux in hippocampal membrane vesicles.
pubmed:affiliation
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912-2300, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't