Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8074
|
| pubmed:dateCreated |
1978-7-24
|
| pubmed:abstractText |
The prophylactic effect of low-dose heparin on postoperative fatal and on clinically apparent but non-fatal thromboembolic complications was studied in a double-blind, prospective, randomised study comprising 1296 patients. 16 out of 653 patients in the placebo group had such complications within the treatment period of 1 week, compared with 4 out of 643 in the heparin group. This difference was statistically significant (P less than 0.05). 4 cases in the placebo group and 1 in the heparin group were fatal. After prophylactic treatment had been stopped at the end of the first postoperative week, the rate of thromboembolic complications was equal for the 2 groups. Low-dose heparin prophylaxis is thus effective and should be given routinely in patients aged over 40 years; it should also be given for more than 1 week in patients not ambulant by then.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Blood Coagulation Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Double-blind Studies,
http://linkedlifedata.com/resource/pubmed/keyword/EMBOLISM,
http://linkedlifedata.com/resource/pubmed/keyword/PULMONARY EMBOLISM,
http://linkedlifedata.com/resource/pubmed/keyword/Postoperative Procedures,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Surgery,
http://linkedlifedata.com/resource/pubmed/keyword/THROMBOEMBOLISM,
http://linkedlifedata.com/resource/pubmed/keyword/THROMBOSIS,
http://linkedlifedata.com/resource/pubmed/keyword/Treatment,
http://linkedlifedata.com/resource/pubmed/keyword/Vascular Diseases
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1115-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:otherAbstract |
PIP: A double-blind prospective study was conducted on 1296 patients who had undergone surgery, to observe the effects of low-dose heparin on postoperative fatal and nonfatal thromboembolic complications. 16 patients out of 652 in the placebo group had such complications within the treatment period of 1 week, compared to 4 out of 643 in the heparin group. There were 4 deaths in the placebo group, and 1 in the heparin group. Rate of thromboembolic complications was equal for both groups after termination of prophylactic treatment. Such study shows that low-dose heparin can be effective when administered routinely to patients over 40, and to patients not ambulant 1 week after operation.
|
| pubmed:meshHeading |
pubmed-meshheading:77413-Adult,
pubmed-meshheading:77413-Age Factors,
pubmed-meshheading:77413-Aged,
pubmed-meshheading:77413-Clinical Trials as Topic,
pubmed-meshheading:77413-Female,
pubmed-meshheading:77413-Heparin,
pubmed-meshheading:77413-Humans,
pubmed-meshheading:77413-Injections, Subcutaneous,
pubmed-meshheading:77413-Leg,
pubmed-meshheading:77413-Male,
pubmed-meshheading:77413-Middle Aged,
pubmed-meshheading:77413-Pelvis,
pubmed-meshheading:77413-Placebos,
pubmed-meshheading:77413-Postoperative Complications,
pubmed-meshheading:77413-Prospective Studies,
pubmed-meshheading:77413-Pulmonary Embolism,
pubmed-meshheading:77413-Research Design,
pubmed-meshheading:77413-Thrombophlebitis
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Prophylaxis against postoperative pulmonary embolism and deep-vein thrombosis by low-dose heparin.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|