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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1995-6-8
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pubmed:abstractText |
Fibrous dysplasia is characterized by intense marrow fibrosis and increased rates of bone turnover. The lesions of fibrous dysplasia resemble those described in the long bones of transgenic mice overexpressing the c-fos proto-oncogene. Activating mutations in the alpha subunit of the stimulatory guanine-nucleotide-binding protein (GS alpha) linked to adenylate cyclase have recently been described in bone cells from patients with the McCune-Albright syndrome and fibrous dysplasia.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-4793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
332
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1546-51
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:7739708-Adolescent,
pubmed-meshheading:7739708-Adult,
pubmed-meshheading:7739708-Child,
pubmed-meshheading:7739708-Child, Preschool,
pubmed-meshheading:7739708-Female,
pubmed-meshheading:7739708-Fibrous Dysplasia of Bone,
pubmed-meshheading:7739708-Gene Expression,
pubmed-meshheading:7739708-Genes, fos,
pubmed-meshheading:7739708-Humans,
pubmed-meshheading:7739708-In Situ Hybridization,
pubmed-meshheading:7739708-Male,
pubmed-meshheading:7739708-Middle Aged,
pubmed-meshheading:7739708-Osteitis Deformans,
pubmed-meshheading:7739708-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:7739708-RNA, Messenger,
pubmed-meshheading:7739708-Rickets
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pubmed:year |
1995
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pubmed:articleTitle |
Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia.
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pubmed:affiliation |
Genetics Unit, Shriners Hospital, Montreal, QC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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