Linked Life Data

773638

Source:http://linkedlifedata.com/resource/pubmed/id/773638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1976-8-2
pubmed:abstractText
Experiments on RNA synthesis and the observation of an increased secretion of proinsulin during stimulated synthesis of insulin in islets of Langerhans in vitro led to the supposition that insulin synthesis in vivo may be increased to a higher extent than synthesis in vitro. This investigation evaluates the effect of long time infusions of glucose on the synthesis of proinsulin and insulin in islets of Langerhans from the rat. The following results were obtained: 1. the rate of synthesis of proinsulin and insulin increased due to glucose infusions by a factor of 2 after 6 hours and by a factor of 4 after 24 hours; 2. prolonged infusion led to a decrease of insulin synthesis and serum insulin concentrations; 3. the turnover of proinsulin into insulin remained unaffected by the glucose infusion; 4. a specific stimulatory effect on the synthesis of one of the two insulins of the rat was not observed. The conclusion was made, that glucose in vivo stimulates enzyme induction, followed by increased RNA synthesis and mitotic activity. These combined factors lead to an increased insulin synthesis.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0013-7251
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
46-55
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
[Influence of glucose infusions on proinsulin and insulin syntheses in the islands of langerhans in the rat].
pubmed:publicationType
Journal Article, English Abstract