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pubmed-article:7734113pubmed:abstractTextTo determine if acute or chronic (21 days) losartan (10 mg/kg, s.c.) regulates the renin-angiotensin system in interscapular brown adipose tissue, angiotensin II (AII) content and [3H]overflow from slices preloaded with [3H]norepinephrine were examined. Acute or chronic losartan administration had no effect on AII content. AII increased evoked [3H] overflow from slices from control rats. Losartan administration did not alter basal [3H]outflow or evoked [3H]overflow. Acute losartan administration inhibited AII-induced enhancement of evoked [3H]overflow. Tolerance developed to the inhibitory effect of losartan following chronic administration.lld:pubmed
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pubmed-article:7734113pubmed:articleTitleAcute and chronic losartan administration: effect on angiotensin II content and modulation of [3H]norepinephrine release from rat interscapular brown adipose tissue.lld:pubmed
pubmed-article:7734113pubmed:affiliationDivision of Pharmacology and Experimental Therapeutics, College of Pharmacy, University of Kentucky, Lexington, USA.lld:pubmed
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