|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0003009,
umls-concept:C0006298,
umls-concept:C0028351,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0126174,
umls-concept:C0205178,
umls-concept:C0205191,
umls-concept:C0391871,
umls-concept:C0456205,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1550605,
umls-concept:C1709059,
umls-concept:C1963578
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1995-6-8
|
|
pubmed:abstractText |
To determine if acute or chronic (21 days) losartan (10 mg/kg, s.c.) regulates the renin-angiotensin system in interscapular brown adipose tissue, angiotensin II (AII) content and [3H]overflow from slices preloaded with [3H]norepinephrine were examined. Acute or chronic losartan administration had no effect on AII content. AII increased evoked [3H] overflow from slices from control rats. Losartan administration did not alter basal [3H]outflow or evoked [3H]overflow. Acute losartan administration inhibited AII-induced enhancement of evoked [3H]overflow. Tolerance developed to the inhibitory effect of losartan following chronic administration.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0300-9564
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
98
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
159-64
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7734113-Adipose Tissue, Brown,
pubmed-meshheading:7734113-Angiotensin II,
pubmed-meshheading:7734113-Animals,
pubmed-meshheading:7734113-Biphenyl Compounds,
pubmed-meshheading:7734113-Imidazoles,
pubmed-meshheading:7734113-Losartan,
pubmed-meshheading:7734113-Male,
pubmed-meshheading:7734113-Norepinephrine,
pubmed-meshheading:7734113-Rats,
pubmed-meshheading:7734113-Rats, Sprague-Dawley,
pubmed-meshheading:7734113-Tetrazoles,
pubmed-meshheading:7734113-Time Factors,
pubmed-meshheading:7734113-Tritium
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Acute and chronic losartan administration: effect on angiotensin II content and modulation of [3H]norepinephrine release from rat interscapular brown adipose tissue.
|
|
pubmed:affiliation |
Division of Pharmacology and Experimental Therapeutics, College of Pharmacy, University of Kentucky, Lexington, USA.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
