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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-5-30
|
| pubmed:abstractText |
In 1982, a treatment protocol was instituted for the management of patients with clinical stage I adenocarcinoma of the endometrium. All pertinent historical, operative, and pathologic findings were reviewed by a multidisciplinary committee and 384 patients were prospectively assigned to either high- or low-risk categories. Patients were excluded from the study if they had clinically apparent extrauterine disease, clear cell or serous histologies, or microscopic ovarian metastasis. Patients were considered high-risk if they had one or more of the following factors: grade 3 tumor differentiation, myometrial invasion > 50% of the total wall thickness, pathologic cervical involvement, or adenosquamous histology. Two-hundred twenty-seven (59%) low-risk patients were followed without further treatment after surgery, while pelvic radiation was recommended for 157 (41%) high-risk patients. The 5-year relapse-free survival rates in the low- and high-risk groups were 95 and 81%, respectively. There were no treatment-related deaths. Severe or life threatening chronic radiotherapy complications occurred in 6 (5%) patients. Multivariate Cox analysis identified the following significant prognostic factors: grade, myometrial invasion, cervix involvement, and age. This treatment protocol represents a safe and effective method of managing patients with carcinoma of the endometrium and spares the need for radiation therapy in the low-risk patient.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0090-8258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
138-44
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7729725-Adenocarcinoma,
pubmed-meshheading:7729725-Aged,
pubmed-meshheading:7729725-Clinical Protocols,
pubmed-meshheading:7729725-Endometrial Neoplasms,
pubmed-meshheading:7729725-Female,
pubmed-meshheading:7729725-Follow-Up Studies,
pubmed-meshheading:7729725-Humans,
pubmed-meshheading:7729725-Middle Aged,
pubmed-meshheading:7729725-Multivariate Analysis,
pubmed-meshheading:7729725-Neoplasm Recurrence, Local,
pubmed-meshheading:7729725-Neoplasm Staging,
pubmed-meshheading:7729725-Postoperative Care,
pubmed-meshheading:7729725-Prognosis,
pubmed-meshheading:7729725-Prospective Studies,
pubmed-meshheading:7729725-Radiotherapy, Adjuvant,
pubmed-meshheading:7729725-Radiotherapy Dosage,
pubmed-meshheading:7729725-Remission Induction,
pubmed-meshheading:7729725-Risk Factors,
pubmed-meshheading:7729725-Survival Rate,
pubmed-meshheading:7729725-Treatment Outcome
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Good outcome associated with a standardized treatment protocol using selective postoperative radiation in patients with clinical stage I adenocarcinoma of the endometrium.
|
| pubmed:affiliation |
Division of Gynecologic Oncology, Hamilton Regional Cancer Center, McMaster University, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|