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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-6-1
|
| pubmed:abstractText |
A multi-modality approach combining surgery with aggressive chemotherapy and radiation is used to treat advanced neuroblastoma. Despite this treatment, children with advanced disease have a 20% 2-year survival rate. Controversy has developed regarding the efficacy of combining aggressive chemotherapy with repeated surgical intervention aimed at providing a complete surgical resection (CSR) of the primary tumor and metastatic sites. Several prospective and retrospective studies have provided conflicting reports regarding the benefit of this approach on overall survival. Therefore, we evaluated the efficacy of CSR versus partial surgical resection (PSR) using a strategy combining surgery with aggressive chemotherapy, radiation, and bone marrow transplantation (BMT) for stage IV neuroblastoma.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1068-9265
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
93-100
|
| pubmed:dateRevised |
2007-7-18
|
| pubmed:meshHeading |
pubmed-meshheading:7728576-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7728576-Bone Marrow Transplantation,
pubmed-meshheading:7728576-Chemotherapy, Adjuvant,
pubmed-meshheading:7728576-Child,
pubmed-meshheading:7728576-Child, Preschool,
pubmed-meshheading:7728576-Combined Modality Therapy,
pubmed-meshheading:7728576-Disease-Free Survival,
pubmed-meshheading:7728576-Female,
pubmed-meshheading:7728576-Follow-Up Studies,
pubmed-meshheading:7728576-Humans,
pubmed-meshheading:7728576-Infant,
pubmed-meshheading:7728576-Life Tables,
pubmed-meshheading:7728576-Male,
pubmed-meshheading:7728576-Neoplasm Staging,
pubmed-meshheading:7728576-Neuroblastoma,
pubmed-meshheading:7728576-Retrospective Studies,
pubmed-meshheading:7728576-Survival Analysis,
pubmed-meshheading:7728576-Survival Rate,
pubmed-meshheading:7728576-Whole-Body Irradiation
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Complete surgical resection combined with aggressive adjuvant chemotherapy and bone marrow transplantation prolongs survival in children with advanced neuroblastoma.
|
| pubmed:affiliation |
Department of Surgery, George Washington University Medical Center, Washington, DC, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|