Linked Life Data

7724916

Source:http://linkedlifedata.com/resource/pubmed/id/7724916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-5-19
pubmed:abstractText
There is general recognition that some glands secrete hormones primarily as a series of pulses. One can generally classify the proposed methods of pulse identification and characterization as either (i) criterion-based, that is, they use a criterion such as a test statistic to identify a rise and/or fall in hormone level within a moving window, or (ii) model-based, that is, they specify a statistical model for the time-varying portion of the signal and estimate its parameters. Using simulated data, we compare and contrast seven criterion-based methods and three model-based methods. The model-based methods perform better in estimating the parameters of interest; they are most effective with the sampling rate chosen so that there are 3-5 samples taken during the half-life of the hormone. At higher sampling rates the methods may overidentify pulses (false positives) and at lower sampling rates they may miss pulses (false negatives), both of which lead to biased estimates for the parameters of the signal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0277-6715
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
A comparison of methods that characterize pulses in a time series.
pubmed:affiliation
Department of Biostatistics, University of Michigan, Ann Arbor 48109-2029, USA.
pubmed:publicationType
Journal Article, Comparative Study