Linked Life Data

7724493

Source:http://linkedlifedata.com/resource/pubmed/id/7724493

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-23
pubmed:abstractText
A new method for estimating dermal absorption including the effects of exposure time and chemistry is described generally in Part 1 of this series. This method accounts for the larger absorption rates during the initial exposure period as well as the hydrophilic barrier which the viable epidermis presents to lipophilic chemicals. A key parameter in this procedure, the ratio of the stratum corneum and epidermis permeabilities (B) depends on molecular weight and octanol-water partitioning. Several approaches for approximating B and its affect on the dermal absorption prediction are discussed here. Generally, the parameter B is only important for highly lipophilic chemicals which also have relatively small molecular weights. When B is important, the recommended prediction for B is based on the Potts and Guy correlation for human stratum corneum permeability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0724-8741
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-95
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
A new method for estimating dermal absorption from chemical exposure: 2. Effect of molecular weight and octanol-water partitioning.
pubmed:affiliation
Chemical Engineering and Petroleum Refining Department, Colorado School of Mines, Golden 80401, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.