Linked Life Data

7723302

Source:http://linkedlifedata.com/resource/pubmed/id/7723302

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-25
pubmed:abstractText
Human serum, autopsy blood, and liver samples were extracted by means of liquid-liquid extraction at acidic and at basic pH and at basic pH following acid hydrolysis. Six selected basic and six selected acidic or neutral drugs were added to the extracts. The spiked and blank samples were examined by means of reversed-phase high-performance liquid chromatography (HPLC) under standardized conditions using diode array detection. The retention index (RI) values of drugs were determined using a 1-nitroalkane scale and secondary standards. The RI values were virtually unaffected by biological matrix. On the other hand, the detection of some substances may be impaired by matrix peaks occurring regularly in biological extracts. The retention index values and UV spectra of three identified (phenethylamine, tryptamine, and indole) and nine unidentified substances were included in an HPLC database.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0146-4760
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Influence of biological matrix on chromatographic behavior and detection of selected acidic, neutral, and basic drugs examined by means of a standardized HPLC-DAD system.
pubmed:affiliation
Institute of Forensic Medicine, Medical Faculty, Aachen University of Technology, Germany.
pubmed:publicationType
Journal Article