| pubmed-article:7721702 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7721702 | lifeskim:mentions | umls-concept:C0085478 | lld:lifeskim |
| pubmed-article:7721702 | lifeskim:mentions | umls-concept:C0023767 | lld:lifeskim |
| pubmed-article:7721702 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:7721702 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:7721702 | lifeskim:mentions | umls-concept:C1996904 | lld:lifeskim |
| pubmed-article:7721702 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:7721702 | lifeskim:mentions | umls-concept:C1880497 | lld:lifeskim |
| pubmed-article:7721702 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7721702 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7721702 | pubmed:dateCreated | 1995-5-19 | lld:pubmed |
| pubmed-article:7721702 | pubmed:abstractText | The chemical structure of lipid A isolated from Porphyromonas gingivalis lipopolysaccharide was elucidated by compositional analysis, mass spectrometry, and nuclear magnetic resonance spectroscopy. The hydrophilic backbone of free lipid A was found to consisted of beta(1,6)-linked D-glucosamine disaccharide 1-phosphate. (R)-3-Hydroxy-15-methylhexadecanoic acid and (R)-3-hydroxyhexadecanoic acid are attached at positions 2 and 3 of the reducing terminal residue, respectively, and positions 2' and 3' of the nonreducing terminal unit are acylated with (R)-3-O-(hexadecanoyl)-15-methylhexadecanoic acid and (R)-3-hydroxy-13-methyltetradecanoic acid, respectively. The hydroxyl group at position 4' is partially replaced by another phosphate group, and the hydroxyl groups at positions 4 and 6' are unsubstituted. Considerable heterogeneity in the fatty acid chain length and the degree of acylation and phosphorylation was detected by liquid secondary ion-mass spectrometry (LSI-MS). A significant pseudomolecular ion of lipid A at m/z 1,769.6 [M-H]- corresponding to a diphosphorylated GlcN backbone bearing five acyl groups described above was detected in the negative mode of LSI-MS. Predominant ions, however, were observed at m/z 1,434.9 [M-H]- and m/z 1,449.0 [M-H]-, each representing monophosphoryl lipid A lacking (R)-3-hydroxyhexadecanoic and (R)-3-hydroxy-13-methyltetradecanoic acids, respectively. The presence of mono- and diphosphorylated lipid A species was also confirmed by LSI-MS of de-O-acylated lipid A (m/z 955.3 and 1,035.2, respectively). | lld:pubmed |
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| pubmed-article:7721702 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7721702 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721702 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7721702 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7721702 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7721702 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:7721702 | pubmed:author | pubmed-author:UmemotoTT | lld:pubmed |
| pubmed-article:7721702 | pubmed:author | pubmed-author:TanamotoKK | lld:pubmed |
| pubmed-article:7721702 | pubmed:author | pubmed-author:KumadaHH | lld:pubmed |
| pubmed-article:7721702 | pubmed:author | pubmed-author:HaishimaYY | lld:pubmed |
| pubmed-article:7721702 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7721702 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:7721702 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7721702 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7721702 | pubmed:pagination | 2098-106 | lld:pubmed |
| pubmed-article:7721702 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7721702 | pubmed:meshHeading | pubmed-meshheading:7721702-... | lld:pubmed |
| pubmed-article:7721702 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7721702 | pubmed:articleTitle | Structural study on the free lipid A isolated from lipopolysaccharide of Porphyromonas gingivalis. | lld:pubmed |
| pubmed-article:7721702 | pubmed:affiliation | Department of Oral Microbiology, Kanagawa Dental College, Japan. | lld:pubmed |
| pubmed-article:7721702 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7721702 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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