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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-5-16
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pubmed:abstractText |
Glycine and glutamate binding sites are allosterically coupled at the N-methyl-D-aspartate (NMDA) receptor complex. Previous studies have shown that antagonism of glutamate at the NMDA receptor reduces the minimum alveolar concentration (MAC) for volatile anesthetics. 5-Nitro-6,7-dichloro-2,3-quinoxalinedione (ACEA-1021) is a competitive antagonist at the glycine recognition site of the NMDA receptor. The purpose of this study was to determine whether glycine receptor antagonism also reduces volatile anesthetic requirements in the rat.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Dioxide,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Halothane,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Strychnine,
http://linkedlifedata.com/resource/pubmed/chemical/licostinel
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
963-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7717569-Animals,
pubmed-meshheading:7717569-Binding, Competitive,
pubmed-meshheading:7717569-Blood Pressure,
pubmed-meshheading:7717569-Body Weight,
pubmed-meshheading:7717569-Carbon Dioxide,
pubmed-meshheading:7717569-Drug Interactions,
pubmed-meshheading:7717569-Glycine,
pubmed-meshheading:7717569-Halothane,
pubmed-meshheading:7717569-Hydrogen-Ion Concentration,
pubmed-meshheading:7717569-Male,
pubmed-meshheading:7717569-Oxygen,
pubmed-meshheading:7717569-Partial Pressure,
pubmed-meshheading:7717569-Pulmonary Alveoli,
pubmed-meshheading:7717569-Quinoxalines,
pubmed-meshheading:7717569-Rats,
pubmed-meshheading:7717569-Rats, Sprague-Dawley,
pubmed-meshheading:7717569-Receptors, Glycine,
pubmed-meshheading:7717569-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:7717569-Strychnine
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pubmed:year |
1995
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pubmed:articleTitle |
Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat.
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pubmed:affiliation |
Department of Anesthesiology, University of Iowa, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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