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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5209
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pubmed:dateCreated |
1995-5-18
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pubmed:abstractText |
Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central unresolved issue in acquired immunodeficiency syndrome (AIDS) pathogenesis is the mechanism underlying this T cell depletion. HIV-1 Tat protein was shown to induce cell death by apoptosis in a T cell line and in cultured peripheral blood mononuclear cells from uninfected donors. This Tat-induced apoptosis was inhibitable by growth factors and was associated with enhanced activation of cyclin-dependent kinases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC2-CDC28 Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/CDK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
268
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
429-31
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7716549-Apoptosis,
pubmed-meshheading:7716549-Base Sequence,
pubmed-meshheading:7716549-CDC2-CDC28 Kinases,
pubmed-meshheading:7716549-Cyclin-Dependent Kinase 2,
pubmed-meshheading:7716549-Cyclin-Dependent Kinases,
pubmed-meshheading:7716549-Enzyme Activation,
pubmed-meshheading:7716549-Gene Products, tat,
pubmed-meshheading:7716549-Genes, tat,
pubmed-meshheading:7716549-HIV-1,
pubmed-meshheading:7716549-Humans,
pubmed-meshheading:7716549-Leukocytes, Mononuclear,
pubmed-meshheading:7716549-Molecular Sequence Data,
pubmed-meshheading:7716549-Protein-Serine-Threonine Kinases,
pubmed-meshheading:7716549-Recombinant Proteins,
pubmed-meshheading:7716549-T-Lymphocytes,
pubmed-meshheading:7716549-Transfection,
pubmed-meshheading:7716549-Tumor Cells, Cultured,
pubmed-meshheading:7716549-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1995
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pubmed:articleTitle |
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.
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pubmed:affiliation |
Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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