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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-5-18
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pubmed:abstractText |
The infra-abdominal (iab) elements in the bithorax complex of Drosophila melanogaster regulate the transcription of the homeotic genes abdominal-A (abd-A) and Abdominal-B (Abd-B) in cis. Here we describe two unusual aspects of regulation by the iab elements, revealed by an analysis of an unexpected complementation between mutations in the Abd-B transcription unit and these regulatory regions. First, we find that iab-6 and iab-7 can regulate Abd-B in trans. This iab trans regulation is insensitive to chromosomal rearrangements that disrupt transvection effects at the nearby Ubx locus. In addition, we show that a transposed Abd-B transcription unit and promoter on the Y chromosome can be activated by iab elements located on the third chromosome. These results suggest that the iab regions can regulate their target promoter located at a distant site in the genome in a manner that is much less dependent on homologue pairing than other transvection effects. The iab regulatory regions may have a very strong affinity for the target promoter, allowing them to interact with each other despite the inhibitory effects of chromosomal rearrangements. Second, by generating abd-A mutations on rearrangement chromosomes that break in the iab-7 region, we show that these breaks induce the iab elements to switch their target promoter from Abd-B to abd-A. These two unusual aspects of iab regulation are related by the iab-7 breakpoint chromosomes that prevent iab elements from acting on Abd-B and allow them to act on abd-A. We propose that the iab-7 breaks prevent both iab trans regulation and target specificity by disrupting a mechanism that targets the iab regions to the Abd-B promoter.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1352698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1354838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1363544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1396564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1425336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-14650432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1680047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1731219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1972049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1979031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1979297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-1979484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2015622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2121595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2162766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2265608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2476281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2482824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2505416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2575066,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2632227,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-2903050,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-3449364,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-7918101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-8096812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-8105875,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7713435-8425891
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Abd-B proteins, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Ubx protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/abd-A protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:geneSymbol |
Abd-B,
Ubx,
abd-A
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
835-48
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7713435-Animals,
pubmed-meshheading:7713435-DNA-Binding Proteins,
pubmed-meshheading:7713435-Drosophila Proteins,
pubmed-meshheading:7713435-Drosophila melanogaster,
pubmed-meshheading:7713435-Enhancer Elements, Genetic,
pubmed-meshheading:7713435-Female,
pubmed-meshheading:7713435-Gene Expression Regulation, Developmental,
pubmed-meshheading:7713435-Gene Rearrangement,
pubmed-meshheading:7713435-Genes, Homeobox,
pubmed-meshheading:7713435-Genes, Insect,
pubmed-meshheading:7713435-Genetic Complementation Test,
pubmed-meshheading:7713435-Homeodomain Proteins,
pubmed-meshheading:7713435-Insect Hormones,
pubmed-meshheading:7713435-Male,
pubmed-meshheading:7713435-Mutation,
pubmed-meshheading:7713435-Nuclear Proteins,
pubmed-meshheading:7713435-Promoter Regions, Genetic,
pubmed-meshheading:7713435-Proteins,
pubmed-meshheading:7713435-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:7713435-Thorax,
pubmed-meshheading:7713435-Transcription Factors,
pubmed-meshheading:7713435-Translocation, Genetic,
pubmed-meshheading:7713435-Y Chromosome
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pubmed:year |
1995
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pubmed:articleTitle |
Cis and trans interactions between the iab regulatory regions and abdominal-A and abdominal-B in Drosophila melanogaster.
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pubmed:affiliation |
Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA.
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pubmed:publicationType |
Journal Article
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