Linked Life Data

7712204

Source:http://linkedlifedata.com/resource/pubmed/id/7712204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-5-15
pubmed:abstractText
Rats were exposed to a potent antagonist of NMDA receptors, 2-amino-5 phosphonovalerate (AP5) by implanting osmotic pumps delivering AP5 (test group) or the vehicle for AP5 (control group) into the cerebrospinal fluid through previously implanted cannulas. A week later they were given the choice of 6% ethanol or water for 1 h. The control group had a significantly greater preference for ethanol than the test group after the first 5 days. Another group of rats was trained almost to a 100% criterion in preferring ethanol to water in the hour the choice was available. Then they were implanted with osmotic pumps and cannulas and administered AP5. These trained rats showed no significant difference between control and test groups in preference for ethanol after the first 5 days. The results support the hypothesis that activation of NMDA receptors is involved in learning to drink ethanol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
421-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
An NMDA receptor antagonist reduces ethanol preference in untrained but not trained rats.
pubmed:affiliation
Department of Physiology, University of Otago Medical School, Dunedin, New Zealand.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't