| pubmed-article:7708722 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7708722 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7708722 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:7708722 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:7708722 | lifeskim:mentions | umls-concept:C0034965 | lld:lifeskim |
| pubmed-article:7708722 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:7708722 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:7708722 | lifeskim:mentions | umls-concept:C0205923 | lld:lifeskim |
| pubmed-article:7708722 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7708722 | pubmed:dateCreated | 1995-5-11 | lld:pubmed |
| pubmed-article:7708722 | pubmed:abstractText | We studied the effects of a high-affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography. Administration of lorazepam to healthy volunteers caused time- and dose-dependent reductions in regional cerebral blood flow and self-reported alterations in behavioral/mood parameters. Flumazenil administration reversed these changes. These observations indicated that benzodiazepine-induced effects on regional cerebral blood flow and mood/behavior are mediated at some level through GABA-benzodiazepine receptors, although the specific mechanism remains unclear. The approach described here provides a method for quantifying GABA-benzodiazepine-receptor-mediated neurotransmission in the living human brain and may be useful for studying the role of these receptors in a variety of neuropsychiatric disorders. | lld:pubmed |
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| pubmed-article:7708722 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7708722 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7708722 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7708722 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7708722 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:JohansonC ECE | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:GreenblattD... | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:KingCC | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:PaulS MSM | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:CohenRR | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:CarsonR ERE | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:PettigrewKK | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:HerscovitchPP | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:AndreasonPP | lld:pubmed |
| pubmed-article:7708722 | pubmed:author | pubmed-author:MatthesAA | lld:pubmed |
| pubmed-article:7708722 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7708722 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:7708722 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7708722 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7708722 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7708722 | pubmed:pagination | 2775-9 | lld:pubmed |
| pubmed-article:7708722 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:7708722 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7708722 | pubmed:articleTitle | Benzodiazepine receptors mediate regional blood flow changes in the living human brain. | lld:pubmed |
| pubmed-article:7708722 | pubmed:affiliation | Clinical Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:7708722 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7708722 | pubmed:publicationType | Comparative Study | lld:pubmed |
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