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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1995-5-11
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pubmed:abstractText |
We studied the effects of a high-affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography. Administration of lorazepam to healthy volunteers caused time- and dose-dependent reductions in regional cerebral blood flow and self-reported alterations in behavioral/mood parameters. Flumazenil administration reversed these changes. These observations indicated that benzodiazepine-induced effects on regional cerebral blood flow and mood/behavior are mediated at some level through GABA-benzodiazepine receptors, although the specific mechanism remains unclear. The approach described here provides a method for quantifying GABA-benzodiazepine-receptor-mediated neurotransmission in the living human brain and may be useful for studying the role of these receptors in a variety of neuropsychiatric disorders.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-12106383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-1315376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-1684872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-1930609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-20632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-2112470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-2171449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-22814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-2835381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-2884547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-2902315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-29907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-3037384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-3105357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-3497161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-3785666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-4041513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-6107064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-6282187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-6292984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-7097270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-7238911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-7250193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-8360281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-8382010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708722-918669
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2775-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7708722-Adult,
pubmed-meshheading:7708722-Affect,
pubmed-meshheading:7708722-Brain,
pubmed-meshheading:7708722-Cerebrovascular Circulation,
pubmed-meshheading:7708722-Dose-Response Relationship, Drug,
pubmed-meshheading:7708722-Flumazenil,
pubmed-meshheading:7708722-Functional Laterality,
pubmed-meshheading:7708722-GABA-A Receptor Agonists,
pubmed-meshheading:7708722-GABA-A Receptor Antagonists,
pubmed-meshheading:7708722-Humans,
pubmed-meshheading:7708722-Kinetics,
pubmed-meshheading:7708722-Lorazepam,
pubmed-meshheading:7708722-Male,
pubmed-meshheading:7708722-Organ Specificity,
pubmed-meshheading:7708722-Oxygen Radioisotopes,
pubmed-meshheading:7708722-Receptors, GABA-A,
pubmed-meshheading:7708722-Reference Values,
pubmed-meshheading:7708722-Regional Blood Flow,
pubmed-meshheading:7708722-Time Factors,
pubmed-meshheading:7708722-Tomography, Emission-Computed
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pubmed:year |
1995
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pubmed:articleTitle |
Benzodiazepine receptors mediate regional blood flow changes in the living human brain.
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pubmed:affiliation |
Clinical Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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