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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10-11
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pubmed:dateCreated |
1995-5-10
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pubmed:abstractText |
Platelet functionality alterations have been correlated to the onset of hypertension in pregnancy and oral Mg++ supplementation has been clinically postulated to counteract such alterations. We, therefore tested the effect of 4 weeks oral Mg++ pyrrolidone carboxylate supplementation on platelet function. Forty-eight pregnant women were enrolled in the study at the beginning of the third trimester (30-32 weeks). Twenty women were preeclamptic, while 28 remained normotensive and served as controls. All the women received 360 mg/day magnesium pyrrolidone carboxylate for 4 weeks. DPH fluorescence, Na+/K(+)-ATPase and Ca(++)-ATPase activity, intracellular free Ca++ concentrations were determined prior and after the 4-weeks supplementation. Oral Mg++ supplementation significantly increased platelet DPH fluorescence in both normotensive and preeclamptic women. In normotensive pregnant women, it also significantly increased the activity of Na+/K(+)-ATPase, the activity of Ca(++)-ATPase and reduced the concentration of intraplatelet free Ca++. In hypertensive pregnant women, Mg supplementation increases Na+/K(+)-ATPase activity and decreases intracellular free Ca++; this, in turn, contributes to reducing the activity of Ca(++)-ATPase. Magnesium supplementation to preventing hypertension in pregnancy seems to have a consistent biochemical and clinical background.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0037-8771
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-56
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7702828-Administration, Oral,
pubmed-meshheading:7702828-Blood Platelets,
pubmed-meshheading:7702828-Calcium-Transporting ATPases,
pubmed-meshheading:7702828-Female,
pubmed-meshheading:7702828-Humans,
pubmed-meshheading:7702828-Hypertension,
pubmed-meshheading:7702828-Magnesium,
pubmed-meshheading:7702828-Pregnancy,
pubmed-meshheading:7702828-Pregnancy Complications, Cardiovascular,
pubmed-meshheading:7702828-Sodium-Potassium-Exchanging ATPase
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pubmed:articleTitle |
Functional platelet modifications induced by oral magnesium supplementation in normotensive and hypertensive pregnancy.
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pubmed:affiliation |
Institute of Gynecology and Obstetrics, University of Ancona.
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pubmed:publicationType |
Journal Article
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