Linked Life Data

7697864

Source:http://linkedlifedata.com/resource/pubmed/id/7697864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-2
pubmed:abstractText
Gamma aminobutyric acid (GABA) is one of the earliest neuroactive substances appearing in the developing central nervous system. The distribution and the time course of the appearance of GABA-like immunoreactivity in the retina of the turtle Emys orbicularis were investigated from embryonic stage 13 to hatching. The first GABA-like immunoreactive cells were observed at stage 14. These cells were located in both the scleral third of the neuroblastic layer and the inner layers of the retina. They were identified as presumptive immature horizontal cells and amacrine cells, respectively. The observation of numerous labelled fibers in the nerve fiber layer suggests that some of the GABA-like immunoreactive cells in the layers were ganglion cells. The development of GABA-like immunoreactive cells followed a gradient of maturation from central to peripheral retina. At hatching, the central retina appeared nearly morphologically mature. In conclusion, GABA is present before the morphofunctional maturation of the retina and this precocious existence supports the idea of its involvement in a neurotrophic role preceding the establishment of synaptic connections and neurotransmitter function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Early development of GABA-like immunoreactive cells in the retina of turtle embryos.
pubmed:affiliation
Laboratoire d'Anatomie Comparée, MNHN, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't