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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1993-8-31
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pubmed:abstractText |
We examined the T-lymphocyte phenotypes of 67 human immunodeficiency virus (HIV)-infected children (P-1 or P-2) and 65 age-matched, healthy, control children stratified into four groups from < 1 to > or = 5 years of age to determine expression of antigens associated with cell activation/differentiation. Immunophenotyping was performed by laser flow cytometry using two-color immunofluorescent labeling. Although the control children showed a decline in total CD4 cell percent with age, the HIV-infected children in all age groups showed significantly decreased CD4 cell numbers compared with the age-matched controls. However, the slope of the CD4 cell decline with age was not significantly different in HIV-infected and control children. The CD4 cell decrease in infected children was reflected in both the CD45RA+ (naive) and CD45RA- (memory) CD4 cell subsets, although the CD45RA+ cells were decreased in greater proportion. Results assessing CD4 cells for expression of the L-selectin (Leu8) molecule were similar to those for CD45RA. The overall CD8 cell percentage was significantly increased in HIV-infected children compared with controls in all age groups. This was due primarily to increases in CD8 cells that were CD38+, CD57+, HLA-DR+, or CD45RA-. In a retrospective analysis of data from 23 P-0 children, we compared phenotype results from 5 children who were HIV+ with those 18 who were HIV-. Although the phenotypic changes seen in the 5 HIV+ children paralleled those described above for P-1 and P-2 subjects, there was no significant difference in the values for HIV+ compared with HIV P-0 children. Although the phenotypic alterations described did not appear to be diagnostic markers in P-0 children, they may serve as useful adjuncts for the evaluation of HIV-infected children.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD57,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0894-9255
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
984-93
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7688045-ADP-ribosyl Cyclase,
pubmed-meshheading:7688045-Aging,
pubmed-meshheading:7688045-Antigens, CD,
pubmed-meshheading:7688045-Antigens, CD38,
pubmed-meshheading:7688045-Antigens, CD4,
pubmed-meshheading:7688045-Antigens, CD45,
pubmed-meshheading:7688045-Antigens, CD57,
pubmed-meshheading:7688045-Antigens, CD8,
pubmed-meshheading:7688045-Antigens, Differentiation,
pubmed-meshheading:7688045-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:7688045-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7688045-Child,
pubmed-meshheading:7688045-Child, Preschool,
pubmed-meshheading:7688045-Flow Cytometry,
pubmed-meshheading:7688045-HIV Infections,
pubmed-meshheading:7688045-HLA-DR Antigens,
pubmed-meshheading:7688045-Humans,
pubmed-meshheading:7688045-Immunophenotyping,
pubmed-meshheading:7688045-Infant,
pubmed-meshheading:7688045-Infant, Newborn,
pubmed-meshheading:7688045-Leukocyte Count,
pubmed-meshheading:7688045-Membrane Glycoproteins,
pubmed-meshheading:7688045-Regression Analysis,
pubmed-meshheading:7688045-Retrospective Studies,
pubmed-meshheading:7688045-T-Lymphocyte Subsets,
pubmed-meshheading:7688045-T-Lymphocytes, Regulatory
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pubmed:year |
1993
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pubmed:articleTitle |
Activation and differentiation antigens on T cells of healthy, at-risk, and HIV-infected children.
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pubmed:affiliation |
Department of Pediatrics, UCLA School of Medicine 90024-1752.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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