| pubmed-article:7686036 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7686036 | lifeskim:mentions | umls-concept:C0039082 | lld:lifeskim |
| pubmed-article:7686036 | lifeskim:mentions | umls-concept:C0439793 | lld:lifeskim |
| pubmed-article:7686036 | lifeskim:mentions | umls-concept:C0019024 | lld:lifeskim |
| pubmed-article:7686036 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:7686036 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:7686036 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:7686036 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:7686036 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7686036 | pubmed:dateCreated | 1993-7-26 | lld:pubmed |
| pubmed-article:7686036 | pubmed:abstractText | Genetic factors determining the difference in severity of anaemia in beta-thalassaemia/HbE disease were studied in 90 patients who had haemoglobin levels, at steady state, ranging from 4.2 to 12.6 g/dl. Co-inheritance of alpha-thalassaemia 2 and haemoglobin Constant Spring could significantly decrease the severity of the disease. Inheritance of a beta-thalassaemia chromosome with Xmn I cleavage site at position -158 of the G gamma-globin gene which was linked to the haplotype -+-++ or ++-++, was associated with a milder anaemia. Two copies of these alleles were necessary to produce a significant clinical effect. Increased expression of the G gamma-globin gene and higher production of haemoglobin F, which could reduce the overall globin chain imbalance, were also associated with homozygosity for the Xmn I cleavage site and thus with less severe anaemia. However, this effect was not seen in Xmn I site heterozygotes. Whether the effects of the Xmn I polymorphism, HbF concentration and G gamma/A gamma ratio act separately or through common mechanisms in reducing anaemia remains to be ascertained. | lld:pubmed |
| pubmed-article:7686036 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7686036 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7686036 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7686036 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7686036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7686036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7686036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7686036 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7686036 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7686036 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:7686036 | pubmed:author | pubmed-author:WasiPP | lld:pubmed |
| pubmed-article:7686036 | pubmed:author | pubmed-author:WilairatPP | lld:pubmed |
| pubmed-article:7686036 | pubmed:author | pubmed-author:FukumakiYY | lld:pubmed |
| pubmed-article:7686036 | pubmed:author | pubmed-author:WinichagoonPP | lld:pubmed |
| pubmed-article:7686036 | pubmed:author | pubmed-author:FucharoenSS | lld:pubmed |
| pubmed-article:7686036 | pubmed:author | pubmed-author:ThonglairoamV... | lld:pubmed |
| pubmed-article:7686036 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7686036 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:7686036 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7686036 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7686036 | pubmed:pagination | 633-9 | lld:pubmed |
| pubmed-article:7686036 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7686036 | pubmed:meshHeading | pubmed-meshheading:7686036-... | lld:pubmed |
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| pubmed-article:7686036 | pubmed:meshHeading | pubmed-meshheading:7686036-... | lld:pubmed |
| pubmed-article:7686036 | pubmed:meshHeading | pubmed-meshheading:7686036-... | lld:pubmed |
| pubmed-article:7686036 | pubmed:meshHeading | pubmed-meshheading:7686036-... | lld:pubmed |
| pubmed-article:7686036 | pubmed:meshHeading | pubmed-meshheading:7686036-... | lld:pubmed |
| pubmed-article:7686036 | pubmed:meshHeading | pubmed-meshheading:7686036-... | lld:pubmed |
| pubmed-article:7686036 | pubmed:meshHeading | pubmed-meshheading:7686036-... | lld:pubmed |
| pubmed-article:7686036 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7686036 | pubmed:articleTitle | Severity differences in beta-thalassaemia/haemoglobin E syndromes: implication of genetic factors. | lld:pubmed |
| pubmed-article:7686036 | pubmed:affiliation | Department of Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand. | lld:pubmed |
| pubmed-article:7686036 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7686036 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7686036 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7686036 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7686036 | lld:pubmed |
