Linked Life Data

7683706

Source:http://linkedlifedata.com/resource/pubmed/id/7683706

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-6-9
pubmed:abstractText
HIV-1 strains were isolated from three patients treated with AZT and from three patients not treated with AZT. Progenomes of HIV-1 RT gene were amplified by PCR and cloned to M13mp18 vecter. Four amino acid mutations in RT gene (Asp67, Lys70, Thr215, Lys219) associated with resistance to AZT were analysed. All of the 14 clones obtained from the three patients with AZT therapy had mutations at codon 215 (Thr-->Tyr or Phe). Some of the 14 clones also had other mutations at codon 67 (Asp-->Asn or Ser), codon 70 (Lys-->Arg) and codon 219 (Lys-->Glu). All of 18 clones obtained from the patients not treated with AZT have no mutation at any codon mentioned above.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0387-5911
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:geneSymbol
RT
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-9
pubmed:dateRevised
2008-12-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Mutations of HIV-1 RT gene isolated from patients treated with AZT].
pubmed:affiliation
Department of Virology, Kanagawa Prefectural Public Health Laboratories.
pubmed:publicationType
Journal Article, English Abstract