Linked Life Data

7682348

Source:http://linkedlifedata.com/resource/pubmed/id/7682348

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-5-11
pubmed:abstractText
The precise regulation of synaptic efficacy in the mammalian central nervous system is fundamental for learning, memory, motor control and sensory processing, as well as synaptogenesis. Currently, the molecular mechanisms underlying synaptic plasticity involved in these crucial processes are topics of intense investigation. The modulation of neurotransmitter receptors has received considerable attention, since these receptors mediate signal transduction at the postsynaptic membranes of chemical synapses. Over the past several years, evidence has suggested that protein phosphorylation of neurotransmitter receptors is a common mechanism for the regulation of receptor function. In this reaction, protein kinases catalyse the transfer of a highly charged phosphate moiety from ATP to serine, threonine or tyrosine residues of a neurotransmitter receptor, thereby altering the charge and/or conformation of the receptor and regulating its function. Phosphorylation of neurotransmitter receptors is reversible, can occur rapidly, and might result in prolonged changes in receptor function. Thus, this modification might play an important role in both short- and long-term changes in synaptic transmission.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-53
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Phosphorylation of amino acid neurotransmitter receptors in synaptic plasticity.
pubmed:affiliation
Dept of Neurology, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
pubmed:publicationType
Journal Article, Review