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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1993-4-20
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pubmed:abstractText |
Superantigens have the ability to stimulate a subset of T cells based upon their expressed TCR beta-chain. It has been demonstrated that the administration of staphylococcal enterotoxin B (SEB) in mice leads to unresponsiveness in V beta 8+ T cells in vivo which are the same T cells that could be stimulated in vitro by this enterotoxin. We present here data on the effect of SEB administration in DBA/2 and (PL/J x SJL)F1 mice on their T cell response to two different T cell determinants, the responses against which are dominated by the use of V beta 8+ T cells. Treatment of mice with SEB not only diminished their primary T cell proliferative response to these determinants, but also was able to effectively reduce the memory T cell response. SEB treatment, however, showed only a modest effect in preventing Ac 1-11-induced experimental autoimmune encephalomyelitis in H-2u mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3062-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7681087-Amino Acid Sequence,
pubmed-meshheading:7681087-Animals,
pubmed-meshheading:7681087-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:7681087-Enterotoxins,
pubmed-meshheading:7681087-Epitopes,
pubmed-meshheading:7681087-Female,
pubmed-meshheading:7681087-Immune Tolerance,
pubmed-meshheading:7681087-Immunologic Memory,
pubmed-meshheading:7681087-Lymphocyte Activation,
pubmed-meshheading:7681087-Male,
pubmed-meshheading:7681087-Mice,
pubmed-meshheading:7681087-Mice, Inbred DBA,
pubmed-meshheading:7681087-Molecular Sequence Data,
pubmed-meshheading:7681087-Myelin Basic Proteins,
pubmed-meshheading:7681087-Myoglobin,
pubmed-meshheading:7681087-Peptide Fragments,
pubmed-meshheading:7681087-Staphylococcus aureus,
pubmed-meshheading:7681087-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
SEB induced anergy: modulation of immune response to T cell determinants of myoglobin and myelin basic protein.
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pubmed:affiliation |
Department of Medicine, Stanford University School of Medicine, CA 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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