Linked Life Data

7680913

Source:http://linkedlifedata.com/resource/pubmed/id/7680913

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-4-22
pubmed:abstractText
It has been observed that neurones have a certain capacity for the upregulation of fast axonal transport, for instance during nerve regeneration or reactive sprouting. However, the molecular regulation of this transport system is largely unknown. We show here by quantitative video-microscopy of endogenous organelles that application of 1 mM db-cAMP increases the velocity of fast axonal transport maximally by 32% within 60 minutes in neonatal hippocampal cells. At the same time, the jump length of the saltatory motions remains largely unchanged. The data suggest that activation of protein kinase A plays a role in the immediate upregulation of axonal transport.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-82
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The fast axonal transport in hippocampal neurones is acutely enhanced by db-cAMP.
pubmed:affiliation
Department of Cellular Physiology, Life Sciences, Janssen Research Foundation, Beerse, Belgium.
pubmed:publicationType
Journal Article