Linked Life Data

7679361

Source:http://linkedlifedata.com/resource/pubmed/id/7679361

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-3-12
pubmed:abstractText
The roles of activin action in chicken limb development were analyzed. Activin enhanced chondrogenesis up to five-fold in a concentration-dependent manner in limb bud micromass cultures, with a half-maximal dose around 30 ng/ml (1.25 nM). The response of limb bud cells (stage 22/23) to activin appeared higher within 24 hr after culture. Activin increased the size of precartilaginous condensations. No corresponding increase in cell number was observed with total DNA or [3H]thymidine incorporation. Activin treatment resulted in increased expression of NCAM in precartilaginous condensations and tenascin in cartilage nodules, suggesting that the mechanism of activin is mediated by increased cell adhesion and recruitment of mesenchymal cells into condensations. Our results demonstrate a novel function of activin and imply that activin, together with other TGF beta superfamily members, is involved in the induction of limb chondrogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
155
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
545-57
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Activin enhances chondrogenesis of limb bud cells: stimulation of precartilaginous mesenchymal condensations and expression of NCAM.
pubmed:affiliation
Department of Pathology, University of Southern California, School of Medicine, Los Angeles 90033.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't