Linked Life Data

7664738

Source:http://linkedlifedata.com/resource/pubmed/id/7664738

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1995-10-10
pubmed:abstractText
The SR proteins represent a family of splicing factors several of which have been implicated in the regulation of sex-specific alternative splicing of doublesex (dsx) pre-mRNA in Drosophila. The dsx gene is involved in Drosophila sex determination. We have identified two RNA target sequence motifs recognized by the SR protein RBP1 from Drosophila using an in vitro selection approach. Several copies of these RBP1 target sequences were found within two regions of the dsx pre-mRNA which are important for the regulation of dsx alternative splicing, the repeat region and the purine-rich polypyrimidine tract of the regulated female-specific 3' splice site. We show that RBP1 target sequences within the dsx repeat region are required for the efficient splicing of dsx pre-mRNA. Moreover, our studies reveal that RBP1 contributes to the activation of female-specific dsx splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1340470, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1454802, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1508718, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1527029, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1531875, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1538748, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1566072, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1577277, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1674449, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1690860, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1717489, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1717938, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1741384, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1824937, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1885003, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1902987, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-1936994, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-2155161, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-2161558, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-2163768, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-2364434, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-2493994, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-2505080, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-3000622, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-3007007, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-3129196, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-6771185, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-7512732, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-7516476, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-7680770, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-7692602, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8013463, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8035814, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8085156, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8139654, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8223480, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8223481, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8253386, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8261509, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8276242, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8321209, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8334698, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8361546, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8385799, http://linkedlifedata.com/resource/pubmed/commentcorrection/7664738-8417324
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DSX protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Insect Hormones, http://linkedlifedata.com/resource/pubmed/chemical/RBP1 protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA Precursors, http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins, http://linkedlifedata.com/resource/pubmed/chemical/tra2 protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
14
pubmed:geneSymbol
dsx
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3987-4000
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...