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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-10-6
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pubmed:databankReference |
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pubmed:abstractText |
The suppressor of Hairy wing (su(Hw)) protein inhibits the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw)-binding sites. This polarity is due to the ability of the su(Hw)-binding region to form a chromatin insulator. Mutations in modifier of mdg4 (mod(mdg4)) enhance the effect of su(Hw) by inhibiting the function of enhancers located on both sides of the su(Hw)-binding region. This inhibition results in a variegated expression pattern, and mutations in mod(mdg4) act as classical enhancers of position-effect variegation. The mod(mdg4) and su(Hw) proteins interact with each other. The mod(mdg4) protein controls the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is transformed into unidirectional repression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-97
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7664338-Alleles,
pubmed-meshheading:7664338-Amino Acid Sequence,
pubmed-meshheading:7664338-Animals,
pubmed-meshheading:7664338-Chromatin,
pubmed-meshheading:7664338-DNA-Binding Proteins,
pubmed-meshheading:7664338-Drosophila Proteins,
pubmed-meshheading:7664338-Drosophila melanogaster,
pubmed-meshheading:7664338-Enhancer Elements, Genetic,
pubmed-meshheading:7664338-Gene Expression Regulation,
pubmed-meshheading:7664338-Genes, Insect,
pubmed-meshheading:7664338-Genes, Suppressor,
pubmed-meshheading:7664338-Leucine Zippers,
pubmed-meshheading:7664338-Molecular Sequence Data,
pubmed-meshheading:7664338-Mutation,
pubmed-meshheading:7664338-Nuclear Proteins,
pubmed-meshheading:7664338-Phenotype,
pubmed-meshheading:7664338-Repressor Proteins,
pubmed-meshheading:7664338-Transcription Factors
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pubmed:year |
1995
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pubmed:articleTitle |
A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.
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pubmed:affiliation |
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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